Hepatic failure, including fatal cases. Noroxin belongs to a class of antibiotics called fluoroquinolones. Noroxin can cause side effects that may be serious or even cause death. If you develop any of the following serious side effects, get medical help right away. Talk with your healthcare provider about whether you should continue to take Noroxin. Before having surgery, tell your doctor or dentist that you are using this medication. How should I store ciprofloxacin?
The CDC does not recommend the use of to prevent traveler's diarrhea, because they can sometimes cause additional problems. Turkey, India, Singapore, Canada, Vanuatu, Mauritius and USA. This adverse reaction most frequently involves the Achilles tendon, and has also been reported with the rotator cuff the shoulder the hand, the biceps, the thumb, and other tendons. Tendinitis or tendon rupture can occur, within hours or days of starting ciprofloxacin, or as long as several months after completion of fluoroquinolone therapy. Tendinitis and tendon rupture can occur bilaterally. Know the medicines you take. Keep a list of your medicines and show it to your healthcare provider and pharmacist when you get a new medicine.
Norfloxacin is eliminated through metabolism, biliary excretion, and renal excretion. Tell your healthcare provider about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal and dietary supplements. Noroxin and other medicines can affect each other causing side effects. Treatment with Zyloprim should be discontinued when the potential for overproduction of uric acid is no longer present. Ask your healthcare provider or pharmacist if you are not sure if your medicine is one that is listed above.
Tendinopathy and Tendon Rupture: Fluoroquinolones, including Noroxin, are associated with an increased risk of tendinitis and tendon rupture in all ages. This adverse reaction most frequently involves the Achilles tendon, and rupture of the Achilles tendon may require surgical repair. Tendinitis and tendon rupture in the rotator cuff the shoulder the hand, the biceps, the thumb, and other tendon sites have also been reported. The risk of developing fluoroquinolone-associated tendinitis and tendon rupture is further increased in older patients usually over 60 years of age, in patients taking corticosteroid drugs, and in patients with kidney, heart or lung transplants. Factors, in addition to age and corticosteroid use, that may independently increase the risk of tendon rupture include strenuous physical activity, renal failure, and previous tendon disorders such as rheumatoid arthritis. Tendinitis and tendon rupture have also occurred in patients taking fluoroquinolones who do not have the above risk factors. Tendon rupture can occur during or after completion of therapy; cases occurring up to several months after completion of therapy have been reported. Noroxin should be discontinued if the patient experiences pain, swelling, inflammation or rupture of a tendon. Patients should be advised to rest at the first sign of tendinitis or tendon rupture, and to contact their healthcare provider regarding changing to a non-quinolone antimicrobial drug.
Where to Buy Zyloprim Online? What Are the Symptoms of Traveler's Diarrhea? Treatment also requires the replacement of fluids and salts lost from diarrhea. This is best achieved by use of an oral rehydration solution such as the World Health Organization oral rehydration salts ORS solution. ORS packets are available at stores or pharmacies in almost all developing countries. Other serious and sometimes fatal adverse reactions, some due to hypersensitivity, and some due to uncertain etiology, have been reported in patients receiving therapy with quinolones, including ciprofloxacin. These events may be severe and generally occur following the administration of multiple doses. In fasting healthy volunteers, at least 30-40% of an oral dose of Noroxin is absorbed. Ciprofloxacin passes into breast milk. You and your healthcare provider should decide whether you will take ciprofloxacin or breastfeed. You should not do both. Central Nervous System CNS side effects may happen as soon as after taking the first dose of Noroxin. Zyloprim per day will require a reduction in dose to approximately one-third to one-fourth of the usual dose of mercaptopurine or azathioprine. FOLOTYN passes into breast milk. Call your healthcare provider if you think your condition is not getting better while you are taking Noroxin. Ciprofloxacin Injection, USP in 5% Dextrose Injection is available as a clear, colorless to slightly yellowish solution. Ciprofloxacin Injection, USP in 5% Dextrose Injection is available in 200 mg and 400 mg strengths.
If unavoidable, monitor for duloxetine toxicity. An intravenous infusion of 400-mg ciprofloxacin given over 60 minutes every 12 hours has been shown to produce an area under the serum concentration time curve AUC equivalent to that produced by a 500-mg oral dose given every 12 hours. An intravenous infusion of 400 mg ciprofloxacin given over 60 minutes every 8 hours has been shown to produce an AUC at steady-state equivalent to that produced by a 750-mg oral dose given every 12 hours. A 400-mg intravenous dose results in a C max similar to that observed with a 750-mg oral dose. An infusion of 200 mg ciprofloxacin given every 12 hours produces an AUC equivalent to that produced by a 250-mg oral dose given every 12 hours Table 10. By D. Tragak. Rush University. 2017. Pain, swelling, tears and inflammation of tendons including the back of the ankle Achilles shoulder, hand, or other tendon sites. HIV-infected patients with recurrent orolabial or genital herpes treated within 48 hours of lesion onset. Other adverse events reported with quinolones include: agranulocytosis, albuminuria, candiduria, crystalluria, cylindruria, dysphagia, elevation of blood glucose, elevation of serum cholesterol, elevation of serum potassium, elevation of serum triglycerides, hematuria, hepatic necrosis, symptomatic hypoglycemia, nystagmus, postural hypotension, prolongation of prothrombin time, and vaginal candidiasis. FAMVIR are headache and nausea. Uncomplicated urethral and cervical gonorrhea due to Neisseria gonorrhoeae. Zyloprim Allopurinol may cause drowsiness. Buy pain relief patch no rx required. TLS and treat promptly. If CDAD is suspected or confirmed, ongoing antibiotic use not directed against C. difficile may need to be discontinued. Appropriate fluid and electrolyte management, protein supplementation, antibiotic treatment of C. difficile, and surgical evaluation should be instituted as clinically indicated. Fluoroquinolones like Noroxin may cause worsening of myasthenia gravis symptoms, including muscle weakness and breathing problems. Call your healthcare provider right away if you have any worsening muscle weakness or breathing problems. combivent
If CDAD is suspected or confirmed, ongoing antibacterial use not directed against C. difficile may need to be discontinued. Aspirin or a non-steroidal anti-inflammatory drug NSAIDS. You should not take NSAIDS during treatment with Aggrenox. Using these medicines with Aggrenox can increase your risk of bleeding. Prescribing Ciprofloxacin Injection in 5% Dextrose Injection in the absence of a proven or strongly suspected bacterial infection or a prophylactic indication is unlikely to provide benefit to the patient and increases the risk of the development of drug-resistant bacteria. As with any potent drug, periodic assessment of organ system functions, including renal, hepatic, and hematopoietic function, is advisable during prolonged therapy. The correct size and frequency of dosage for maintaining the serum uric acid just within the normal range is best determined by using the serum uric acid level as an index. May 10, 2017. Buy Zyloprim Online - Canadian Pharmacy Online, Canada. Nursing Mothers: Allopurinol and oxipurinol have been found in the milk of a mother who was receiving Zyloprim. Since the effect of allopurinol on the nursing infant is unknown, caution should be exercised when Zyloprim is administered to a nursing woman. Zyloprim can substantially reduce serum and urinary uric acid levels in previously refractory patients even in the presence of renal damage serious enough to render uricosuric drugs virtually ineffective. Salicylates may be given conjointly for their antirheumatic effect without compromising the action of Zyloprim. This is in contrast to the nullifying effect of salicylates on uricosuric drugs. An Independent Pediatric Safety Committee IPSC reviewed all cases of musculoskeletal adverse reactions including abnormal gait or abnormal joint exam baseline or treatment-emergent. It is safer to drink from an unopened can or bottle than from a container that is not known to be clean and dry. Water on the surface of a beverage can or bottle may also be contaminated. Therefore, the area of a can or bottle that will touch the should be wiped clean and dried. Where water may be contaminated, you should not brush your with tap water. If you are taking this medication to raise the level of antibiotics in your body, follow your doctor's directions for when to take the antibiotic and when to take the probenecid. December 5, 2016. Zyloprim Allopurinol Drug Overview of Drug. Therapy in such patients should be carefully assessed initially and reassessed periodically to determine in each case that treatment is beneficial and that the benefits outweigh the risks. Norfloxacin had no mutagenic activity in vitro in the Ames microbial mutagen test, Chinese hamster fibroblasts and V-79 mammalian cell assay. Although norfloxacin was weakly positive in the Rec-assay for DNA repair, all other mutagenic assays were negative including a more sensitive test V-79. This medicine will help prevent gout attacks but it will not relieve an attack that has already started. Even if you take another medicine for gout attacks, continue to take this medicine also. If you have any questions about this, check with your doctor. In several instances, nausea, vomiting, tremor, irritability, or palpitation were judged by investigators to be related to elevated serum levels of theophylline possibly as a result of drug interaction with ciprofloxacin. keva.info perindopril
Ciprofloxacin Injection in 5% Dextrose Injection is indicated in adult patients for treatment of skin and skin structure infections caused by Escherichia coli, Klebsiella pneumoniae, Enterobacter cloacae, Proteus mirabilis, Proteus vulgaris, Providencia stuartii, Morganella morganii, Citrobacter freundii, Pseudomonas aeruginosa, methicillin-susceptible Staphylococcus aureus, methicillin-susceptible Staphylococcus epidermidis, or Streptococcus pyogenes. April 5, 2016. Zyloprim Online Sale; Buy Zyloprim No Prescription Canada. After intravenous administration, three metabolites of ciprofloxacin have been identified in human urine which together account for approximately 10% of the intravenous dose. The metabolites have antimicrobial activity, but are less active than unchanged. Ciprofloxacin is an inhibitor of human cytochrome P450 1A2 CYP1A2 mediated metabolism. It should also be noted that Zyloprim is generally better tolerated if taken following meals. A fluid intake sufficient to yield a daily urinary output of at least 2 liters and the maintenance of a neutral or, preferably, slightly alkaline urine are desirable. This medication may interfere with certain laboratory tests including urine glucose tests possibly causing false test results. Make sure laboratory personnel and all your doctors know you use this drug. After intravenous administration, ciprofloxacin is widely distributed throughout the body. Tissue concentrations often exceed serum concentrations in both men and women, particularly in genital tissue including the prostate. Ciprofloxacin is present in active form in the saliva, nasal and bronchial secretions, mucosa of the sinuses, sputum, skin blister fluid, lymph, peritoneal fluid, bile, and prostatic secretions. Ciprofloxacin has also been detected in lung, skin, fat, muscle, cartilage, and bone. The drug diffuses into the cerebrospinal fluid CSF; however, CSF concentrations are generally less than 10% of peak serum concentrations. Low levels of the drug have been detected in the aqueous and vitreous humors of the eye. discount atrovent price
When only the serum creatinine level is available, the following formula based on sex, weight, and age of the patient may be used to convert this value into creatinine clearance. The serum creatinine should represent a steady state of renal function. In patients with severe infections and severe renal impairment and hepatic insufficiency, careful monitoring is suggested. What should I tell my healthcare provider before taking FAMVIR? Rdiastereomer were comparable across cohorts. Hepatotoxicity: Inform patients that severe hepatotoxicity including acute hepatitis and fatal events has been reported in patients taking ciprofloxacin. Instruct patients to inform their physician if they experience any signs or symptoms of liver injury including: loss of appetite, nausea, vomiting, fever, weakness, tiredness, right upper quadrant tenderness, itching, yellowing of the skin and eyes, light colored bowel movements or dark colored urine. Want Zyloprim with DISCOUNT? PACKAGE INSERT. USE ONLY IF SOLUTION IS CLEAR. Long-term safety data, including effects on cartilage, following the administration of ciprofloxacin to pediatric patients are limited. Ciprofloxacin serum concentrations achieved in humans serve as a surrogate endpoint reasonably likely to predict clinical benefit and provide the basis for this indication. Keep container tightly closed. You may need a lower dose of Noroxin if your kidneys do not work well. Drug information on Zyloprim allopurinol includes drug pictures, side effects, drug interactions, directions for use, symptoms of overdose, and what to avoid.
Ciprofloxacin is a fluoroquinolone antibacterial medicine used in adults age 18 years and older to treat certain infections caused by certain germs called bacteria. In the event of acute overdosage, the stomach should be emptied by inducing vomiting or by gastric lavage, and the patient carefully observed and given symptomatic and supportive treatment. Adequate hydration must be maintained. Pharmacokinetic studies of the oral single dose and intravenous single and multiple dose forms of ciprofloxacin indicate that plasma concentrations of ciprofloxacin are higher in elderly subjects older than 65 years as compared to young adults. Although the C max is increased 16% to 40%, the increase in mean AUC is approximately 30%, and can be at least partially attributed to decreased renal clearance in the elderly. In a randomized, double-blind, placebo-controlled trial conducted in 304 black and adults with recurrent genital herpes there was no difference in median time to healing between patients receiving FAMVIR or placebo. December 22, 2016. Buy Zyloprim Allopurinol Online 100mg 300mg Generic. Tendon problems can happen in people of all ages who take ciprofloxacin. Tendons are tough cords of tissue that connect muscles to bones. February 25, 2017. Prednisone Canada Pharmacy. High-Quality medications. The Arthritis Foundation says the two best exercises for people with arthritis are walking and water aerobics. Both are easy on the joints and good for those who are overweight or just starting to exercise. They improve heart health and physical conditioning. You don't need to know how to swim to do water aerobics. In preliminary studies in patients with stable chronic liver cirrhosis, no significant changes in ciprofloxacin pharmacokinetics have been observed. The kinetics of ciprofloxacin in patients with acute hepatic insufficiency, have not been fully studied. The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs. buy redustat hygien
April 9, 2016. Buy Zyloprim online - Cheap Allopurinol from. Who should not take Noroxin? Pseudomembranous colitis, hepatitis, jaundice including cholestatic jaundice and elevated liver function tests, pancreatitis rare stomatitis. December 29, 2016. Buy Zyloprim Safe. How To Buy Zyloprim In Canada. - One. April 25, 2016. CABIRON TRAITEUR - cabiron. What are the possible side effects of FAMVIR? buy zantac stool softener
It is not known whether famciclovir prodrug or penciclovir active drug are excreted in human milk. Following oral administration of famciclovir to lactating rats, penciclovir was excreted in breast milk at concentrations higher than those seen in the plasma. There are no data on the safety of FAMVIR in infants. FAMVIR should not be used in nursing mothers unless the potential benefits are considered to outweigh the potential risks associated with treatment. How Can I Buy Zyloprim Online. TLS and treat you for TLS if needed. Consultoria, Capacitacion en HSEQ, servicios in house, on line, entrenamientos, cultura y mejora continua en HSEQ-CORGASA, cursos y entrenamientos a medida. What are the ingredients in FAMVIR? Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco. aprovel
This can lead to TLS. Manufactured for: Spectrum Pharmaceuticals, Inc. Serious heart rhythm changes QT prolongation and torsade de pointes. Tell your healthcare provider right away if you have a change in your heart beat a fast or irregular heartbeat or if you faint. Ciprofloxacin may cause a rare heart problem known as prolongation of the QT interval. This condition can cause an abnormal heartbeat and can be very dangerous. May 5, 2016. ZYLOPRIM Allopurinol dosage, indication, interactions. White, round film-coated, biconvex, beveled edges, debossed with “FAMVIR” on one side and “250” on the other. April 10, 2016. Zyloprim - Uses, Side Effects, Interactions - Canada. Noroxin from working correctly. The most frequently reported adverse reaction in post-marketing experience is rash. Zyloprim Available In Generic! In patients with reduced renal function, the half-life of ciprofloxacin is slightly prolonged.
There were no overall differences in the duration of pain before rash healing between FAMVIR-and placebo-treated groups. In addition, there was no difference in the incidence of pain after rash healing between the treatment groups. In the 186 patients 44. It is important for an infected person to consult a doctor about treating diarrhea in children and infants, because some of the drugs mentioned above are not recommended for children. RxList is part of the WebMD Health Network. The opinions expressed in the WebMD User Reviews are solely those of the User, who may or may not have medical or scientific training, and do not represent the opinions of WebMD. These member reviews have not been reviewed by a WebMD physician or any member of the WebMD editorial staff for accuracy, balance, objectivity, or any other purpose except for compliance with our Terms and Conditions. Fluoroquinolones, including ciprofloxacin, have been associated with an increased risk of central nervous system CNS effects, including convulsions, increased intracranial pressure including pseudotumor cerebri and toxic psychosis. Accordingly, maintenance doses of colchicine generally should be given prophylactically when Zyloprim is begun. Zyloprim and its primary active metabolite, oxipurinol, are eliminated by the kidneys; therefore, changes in renal function have a profound effect on dosage. In patients with decreased renal function or who have concurrent illnesses which can affect renal function such as hypertension and diabetes mellitus, periodic laboratory parameters of renal function, particularly BUN and serum creatinine or creatinine clearance, should be performed and the patient's dosage of Zyloprim reassessed. Each tablet contains 400 mg of Norfloxacin. November 27, 2016. What Is Desoximetasone Ointment Used For? Worsening of myasthenia gravis a problem that causes muscle weakness. Fluoroquinolones like ciprofloxacin may cause worsening of myasthenia gravis symptoms, including muscle weakness and breathing problems. Tell your healthcare provider if you have a history of myasthenia gravis before you start taking ciprofloxacin. Call your healthcare provider right away if you have any worsening muscle weakness or breathing problems. Loss of too much fluid from the body dehydration. If you feel tired and weak this could be a sign of dehydration. Ciprofloxacin is an inhibitor of the hepatic CYP1A2 enzyme pathway. November 28, 2016. Dezimalzahlen runden - mathe-lexikon. The recommended dosage of FAMVIR for the treatment of recurrent orolabial or genital herpes in HIV-infected patients is 500 mg twice daily for 7 days. In utero exposure to fluoroquinolones during embryogenesis was not associated with increased risk of major malformations. generic truvada quick shipping
The flexible plastic container is latex-free and is fabricated from a specially formulated polyvinyl chloride. Solutions in contact with the plastic container can leach out certain of its chemical components in very small amounts within the expiration period, for example, di2-ethylhexyl phthalate DEHP up to 5 parts per million. The suitability of the plastic has been confirmed in tests in animals according to USP biological tests for plastic containers as well as by tissue culture toxicity studies. When available, the clinical microbiology laboratory should provide the results of in vitro susceptibility test results for antimicrobial drug products used in resident hospitals to the physician as periodic reports that describe the susceptibility profile of nosocomial and community-acquired pathogens. These reports should aid the physician in selecting an antibacterial drug product for treatment. Naturopathic Health Centre in Halifax Nova Scotia - we specialize in Functional Medicine, Acupuncture, Specialized Lab Testing, Hormone therapy, digestive complaints. The use of colchicine or anti-inflammatory agents may be required to suppress gouty attacks in some cases. The attacks usually become shorter and less severe after several months of therapy. The mobilization of urates from tissue deposits which cause fluctuations in the serum uric acid levels may be a possible explanation for these episodes. Even with adequate therapy with Zyloprim, it may require several months to deplete the uric acid pool sufficiently to achieve control of the acute attacks. Avoid sunlamps, tanning beds, and try to limit your time in the sun. Ciprofloxacin can make your skin sensitive to the sun photosensitivity and the light from sunlamps and tanning beds. You could get a severe sunburn, blisters or swelling of your skin. If you get any of these symptoms while you take ciprofloxacin, call your healthcare provider right away. You should use a sunscreen and wear a hat and clothes that cover your skin if you have to be in sunlight. Food and Drug Administration. Lorazepam comes as a tablet and concentrate liquid to take by mouth. It usually is taken two or three times a day and may be taken with or without food. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take lorazepam exactly as directed. stromectol
Another prospective follow-up study reported on 549 pregnancies with fluoroquinolone exposure 93% first trimester exposures. 4 There were 70 ciprofloxacin exposures, all within the first trimester. The malformation rates among live-born babies exposed to ciprofloxacin and to fluoroquinolones overall were both within background incidence ranges. No specific patterns of congenital abnormalities were found. The study did not reveal any clear adverse reactions due to in utero exposure to ciprofloxacin. Casino. One of the premier Calgary hotels, located in the South, this full service hotel features 188 deluxe guest rooms, a conference center for. In cell culture studies, penciclovir is inhibitory to the following herpes viruses: HSV-1, HSV-2 and VZV. The antiviral activity of penciclovir against wild type strains grown on human fibroblasts was assessed with a plaque reduction assay and staining with crystal violet 3 days postinfection for HSV and 10 days postinfection for VZV. Musculoskeletal Disorders in Pediatric Patients: Instruct parents to inform their child's physician if the child has a history of joint-related problems before taking this drug. The concomitant use of nitrofurantoin is not recommended since nitrofurantoin may antagonize the antibacterial effect of Noroxin in the urinary tract. Based on patient reported data; not necessarily confirmed by a physician. These reactions may occur following the first dose. Advise patients receiving ciprofloxacin to inform their healthcare provider immediately if these reactions occur, discontinue the drug, and institute appropriate care. Ciprofloxacin, like other fluoroquinolones, is known to trigger seizures or lower the seizure threshold. As with all fluoroquinolones, use ciprofloxacin with caution in epileptic patients and patients with known or suspected CNS disorders that may predispose to seizures or lower the seizure threshold for example, severe cerebral arteriosclerosis, previous history of convulsion, reduced cerebral blood flow, altered brain structure, or stroke or in the presence of other risk factors that may predispose to seizures or lower the seizure threshold for example, certain drug therapy, renal dysfunction. Use ciprofloxacin when the benefits of treatment exceed the risks, since these patients are endangered because of possible undesirable CNS side effects. Cases of status epilepticus have been reported. Allopurinol is an inhibitor of xanthine oxidase, a substance in the body that is responsible for the product of uric acid. Clinical and Laboratory Standards Institute, Performance standards for antimicrobial disk susceptibility tests - Tenth edition, Approved Standard CLSI Document M2-A10, Vol. 29, No. 1, CLSI, Wayne, PA, 2009. Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use Noroxin for a condition for which it is not prescribed. Do not give Noroxin to other people, even if they have the same symptoms that you have. It may harm them. April 6, 2016. Buy Zyloprim Allopurinol Cheap Brand Zyloprim, Online. The recommended dosage of FAMVIR for chronic suppressive therapy of recurrent episodes of genital herpes is 250 mg twice daily. Careful monitoring of clozapine associated adverse reactions and appropriate adjustment of clozapine dosage during and shortly after co-administration with ciprofloxacin are advised. May 31, 2016. ZYLOPRIM Allopurinol dosage, indication, interactions. Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. May 15, 2017. Zyloprim - Utilisations, Effets secondaires, Interactions.
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This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist. Sensitivity to sunlight photosensitivity. See " What should I avoid while taking Noroxin? Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Probenecid is available only with your doctor's prescription. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. Advise the patient to read the FDA-approved patient labeling Patient Information. Hearing loss, tinnitus, diplopia, dysgeusia.
Keep Noroxin and all medicines out of the reach of children. Noroxin should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. Potential increase in the risk of methotrexate associated toxic reactions. Therefore, carefully monitor patients under methotrexate therapy when concomitant ciprofloxacin therapy is indicated. June 19, 2016. Pharmacy Online - Canadian Pharmacy Online. Cheap Prices.
Theophylline: Inform patients that ciprofloxacin may increase the effects of theophylline. Life-threatening CNS effects and arrhythmias can occur. Advise the patients to immediately seek medical help if they experience seizures, palpitations, or difficulty breathing. Generic Zyloprim Allopurinol Zyloprim limits the production of xanthine oxidase, a substance that produces uric acid in the body. It is prescribed for preventing. Sometimes after starting the treatment with antibiotics, patients can develop watery and bloody stools with or without stomach cramps and fever even as late as two or more months after having taken the last dose of the antibiotic. If this occurs, patients should contact their physician as soon as possible.